Circular dichroism as a means to follow DNA gymnastics: on the shoulders of giants

  • M. Mills
  • C. Lin
  • M. Chauhan
  • H.H. Klump


This is the first report of DNA stem-loops self-assembled by ‘foot-loop’ interactions into either two-dimensional strings or three-dimensional spirals, distinguished by circular dichroism spectroscopy. All subunits are linked by cooperative Watson-Crick hydrogen bonds.